Hezkue Spray

The Marketing Authorizations are an important achievement. They validate Aspargo’s international regulatory strategy and confirm that Aspargo meets the highest standards required to ensure the safe distribution of sildenafil spray,” said Michael Demurjian, Chairman and Chief Executive Officer of Aspargo.

Hezkue 12.5mg per actuation, oral suspension was developed by the specialty pharmaceutical group Aspargo women sildenafil Laboratories Inc.

What are the possible side effects of Hezkue spray

Kaplan, the chief medical officer at Aspargo Labs, director of the Men’s Wellness Program at the Mount Sinai Health System and professor at the Icahn School of Medicine at Mount Sinai, reflected on the challenges of prescribing ED medications due to issues with convenience and food effects, which can reduce spontaneity and efficacy. Many patients, he explained, are unaware that taking these medications with food can reduce their effectiveness, leading to frustration and treatment failure. The goal, therefore, is to create a more convenient, rapid-acting ED medication without food interference. The introduction of a new delivery system shows promise in overcoming these challenges. This faster absorption could reduce the necessary dosage and side effects while improving overall efficacy.

5.1 Hypotension

The hope is that faster absorption will lead to quicker results, helping patients avoid more invasive treatments like penile injections or surgeries. The medication is currently in the testing phase, focusing on its food effects, absorption rate and overall efficacy. Kaplan and his team aim to receive US Food and Drug Administration (FDA) approval in the US by 2025. This innovation is not just about creating new drugs, he said, but also repurposing existing medications with better delivery methods to enhance patient outcomes. The integration of new technology, such as a discrete and convenient delivery device, is also seen as a major advancement in ED treatment. in partnership with their commercialization consultant, Syneos Health.

• Sildenafil spray provides an alternative to pills for ED.
• It is designed to bypass gastrointestinal absorption.
• Use the spray about 15-30 minutes before intimacy.
• The spray formulation reduces the risk of systemic side effects.
• Patients with heart conditions should consult a doctor before use.
• Sildenafil spray is sometimes used in clinical studies.
• Proper application involves spraying beneath the tongue.
• It is crucial to avoid eating or drinking immediately after.
• The spray may be more discreet than oral pills.
• It is not suitable for individuals under 18 years old.
• Regular medical check-ups are recommended while using.

The 2 groups held focus groups and conducted surveys with physicians, pharmacists, and patients throughout the development process. Aspargo uses a metered-dose pump so that it can deliver the precise, customized dose per push based on the needs of the patient.

According to Aspargo, Sildenafil spray is also discreet, easy to carry, and allows patients to avoid crushing or splitting pills with the traditional tablet medications currently available for ED. Aspargo Laboratories is currently seeking FDA approval to market Sildenafil spray in the United States. Aspargo receives regulatory approval to market sildenafil spray in Germany, Ireland, and the Netherlands.

Highlights of Prescribing Information

We can provide tablets that last for longer than 4 hours or get to work within 15 minutes, or suggest over-the-counter alternatives to suit your needs. If you’re not sure if your symptoms are being caused by erectile dysfunction, you can order an at-home ED test kit. Here are some of the common erectile dysfunction medications available that can only be obtained with a prescription from a doctor. It is also available in a generic form, in 3 different doses (25mg, 50mg, and 100mg). Viagra 50mg tablets are effective in 74% of people compared to a placebo.

12.1 Sildenafil Oral Suspension Mechanism of Action

Cialis contains the active ingredient tadalafil and is the longest-lasting ED medication, providing effective relief for up to 36 hours. It is available in tablet form and is effective in more than 80% of people who take it. Cialis is also available as generic tadalafil. Spedra (avanafil) is a fast-acting erectile dysfunction tablet that gets to work in just 15 to 30 minutes. The effectiveness of the different Spedra doses is as follows: Vardenafil is a generic ED medication that is similar to sildenafil and is 80% effective. Conventional treatments for erectile dysfunction (ED) require planning and may cause timing anxiety with delayed onset of action.1 Hezkue®, a sildenafil suspension, is the first phosphodiesterase type 5 (PDE-5) inhibitor suspension spray for ED that offers flexible dose adjustment based on individual patient needs.2 The below is a MIMS summary of the Hezkue® product characteristics.

12. Sildenafil Oral Suspension - Clinical Pharmacology

Overall, he emphasized that innovation in medical treatments continues to evolve, providing hope and better health outcomes for patients struggling with ED. The spray is a liquid suspension of sildenafil citrate administered orally via a spray pump. The German Federal Institute for Drugs and Medical Devices has granted regulatory approval to market Sildenafil oral spray (trade name, Hezkue) for erectile dysfunction (ED) in Germany. The spray was also recently approved for marketability in Ireland and the Netherlands, according to a news release from Aspargo Laboratories, the developer of the treatment.1 The German market is the largest in the EU, and the aggregate erectile dysfunction market for Germany, Ireland, and the Netherlands exceeds $175 million. “These product approvals reflect Aspargo’s commitment to quickly expand its global platform to the EU during 2023. Please refer to the full Summary of Product Characteristics (SPC) before prescribing.

Erectile dysfunction spray side effects

Vardenafil is more potent than Viagra, lasts longer, and is suitable for people with diabetes. Not all ED treatments require a prescription. Here are some of the options available over the counter or without a prescription: Viagra Connect – A non-prescription version of Viagra that contains 50mg of sildenafil. Superdrug sildenafil – A generic version of Viagra Connect that’s cheaper, but just as effective. Cialis Together – An over-the-counter version of Cialis that contains 10mg of tadalafil, which improves erections in 81% of people and can last for up to 36 hours.

2. Sildenafil Oral Spray(Silfin)

Eroxon gel – A topical gel that’s applied directly to the head of the penis to stimulate the nerve endings, resulting in an erection. It does not contain an active ingredient, so it has few side effects and helps 60% of people get an erection within 10 minutes. Penis pump – A manually operated device that can increase blood flow to the penis to help you get and maintain an erection. A penis pump does not contain any medication, so it may be a suitable alternative if you would prefer not to take drugs to treat erectile dysfunction. Although drinking a small amount of alcohol is generally considered safe while taking Hezkue, it is not recommended because it can reduce its effectiveness and make erectile dysfunction worse. INDICATIONAdult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for Hezkue to be effective, sexual stimulation is required. DOSAGEAdult: Recommended dose is 50mg (4 actuations) orally approx 1 hr before sexual activity. This may be decreased to 25mg (2 actuations) or increased to 100mg (8 actuations) as needed; max 100mg once daily.

Related/similar drugs

Alcohol may also enhance the side effects of Hezkue spray, such as feeling sick or lightheadedness. No, you must not use Hezkue with any other erectile dysfunction medications, as this can increase the chance of side effects. If you sildenafil 130mg do not think that Hezkue is working for you, contact your doctor for advice, as they may recommend an alternative ED treatment. There are no special storage instructions for Hezkue, but it must be kept out of sight and reach of children and pets. Do not use the Hezkue spray after the expiry date.

Can I buy Hezkue spray over the counter?

Once you have opened the bottle, it must be used within 10 months. Hezkue has a mint flavour which helps to cover up the naturally bitter taste of sildenafil. Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction, PubMed [accessed 16 August 2025] Efficacy and Treatment Satisfaction with On-Demand Tadalafil (Cialis®) in Men with Erectile Dysfunction, European Urology [accessed 16 August 2025] Efficacy of Sildenafil oral spray for the treatment of erectile dysfunction in patients with type 2 diabetes mellitus and prediabetes, PubMed [accessed 15 August 2025] Hezkue Sildenafil Suspension, Aspargo Labs [accessed 15 August 2025] PD52-07 EFFICACY AND SAFETY OF MED3000, A NOVEL TOPICAL THERAPY FOR THE TREATMENT OF ERECTILE DYSFUNCTION, The Journal of Urology [accessed 16 August 2025] Sildenafil 50 mg film-coated tablets, emc [accessed 15 August 2025] Spedra 200 mg tablets, emc [accessed 16 August 2025] Who can and cannot take sildenafil, NHS [accessed 16 August 2025] A new sildenafil oral spray, ASP-001, currently under investigation, shows promise in treating erectile dysfunction. In an interview with The Educated Patient, Steven Kaplan, MD, discussed an investigative sildenafil oral spray, ASP-001, that is currently in development for the treatment of erectile dysfunction (ED). Results of a phase 1 study published in the International Journal of Science and Research, revealed the spray achieves absorption beginning at five minutes, which is twice as fast as traditional sildenafil tablets. CONTRAINDICATIONSHypersensitivity to the active substance or excipients.

• Sildenafil spray is approved in some regions for ED.
• It may provide a more convenient dosing method.
• Users should avoid driving until effects are known.
• The spray’s rapid absorption may enhance spontaneity.
• It is important to monitor blood pressure when using.
• Sildenafil spray should not be used with grapefruit juice.
• It’s essential to disclose all health conditions to the doctor.
• The spray formulation might reduce medication costs.
• It can be part of a healthy lifestyle for better results.
• Consistent application improves and prolongs effectiveness.
• Always consult healthcare providers before starting.

Cardiac conditions where sexual activity is inadvisable, non-arteritic anterior ischaemic optic neuropathy, severe hepatic impairment, hypotension, recent stroke or MI, hereditary degenerative retinal disorders.

• Sildenafil spray is a modern alternative for ED therapy.
• It reduces the waiting time before sexual activity.
• The spray is generally well-tolerated with proper use.
• It might be prescribed for specific health conditions.
• The method of administration differs from oral tablets.
• Use of the spray should be coordinated with a doctor.
• It can be used alongside other treatments under supervision.
• The spray dose can be adjusted for optimal response.
• Patients should report any unusual symptoms promptly.
• Sildenafil spray offers privacy compared to other methods.
• Read all warnings and precautions on product packaging.

WARNINGSCardiovascular disease, left ventricular outflow obstruction, severe autonomic dysfunction, severe renal impairment (CrCl <30ml/min), mild to moderate hepatic impairment. Abnormal penile anatomy or predisposition to priapism (eg, sickle cell anaemia, multiple myeloma or leukaemia).

Advise patients to report immediately any sudden changes in vision (and to discontinue treatment if occur) or erection lasting >4 hrs. Common: dizziness, visual colour distortions, visual disturbance, vision blurred, flushing, nasal congestion, nausea, dyspepsia.

• Sildenafil spray utilizes absorption through oral mucosa.
• It provides a discreet alternative for erectile issues.
• Use the spray about 10-20 minutes before intimacy.
• It generally has fewer gastrointestinal side effects.
• The spray must be kept out of reach of children.
• Users should avoid alcohol to prevent adverse reactions.
• Compatibility with other medications should be checked.
• The spray may be part of a comprehensive ED treatment plan.
• Discontinue use and consult a doctor if adverse reactions occur.
• The spray’s effectiveness can improve confidence in men.
• Training on proper application enhances safety and effectiveness.

● Hezkue® is the first PDE-5 inhibitor suspension spray for erectile dysfunction that offers flexible dose adjustment based on individual patient needs.2 Hezkue® uses a suspension technology that provides fast absorption starting within 5 minutes.2–4● A prospective open-label, single-centre, two-way crossover study evaluated the pharmacokinetics, safety and tolerability of 100mg of sildenafil oromucosal spray (8 pumps) and 100mg sildenafil (Viagra®) tablets in 52 fasted healthy male volunteers.3 ● Initial absorption of sildenafil oromucosal spray was observed within 5 minutes of administration, while sildenafil tablets showed no absorption at that time.